Given that “Open Science” is becoming a popular policy object around the world, this study sought to identify key narratives about Open Science in policy, and critically examine the extent to which they are sustaining or strengthening multi-layered domination and inequality schemes that pre-exist in scientific knowledge production. To do so, we conducted a content analysis of Open Science policies stemming from Europe, North America, Latin America, Asia and Africa to understand which narratives about Open Science policies are produced, reproduced and by whom; and in turn, whose interests may be neglected in this process. We found that Open Science policies, mostly stemming from Europe, frame “openness” as a vehicle to promote technological change as part of an inevitable and necessary cultural shift to modernity in scientific production. The global reach of these narratives, and the technologies, standards and models these narratives sustain, are dictating modes of working and collaborating among those who can access them, and creating new categories of exclusion that invalidate knowledge that cannot meet this criteria, putting historically marginalized researchers and publics at further disadvantage.